Long-Range Regulatory Synergy Is Required to Allow Control of the TAC1 Locus by MEK/ERK Signalling in Sensory Neurones

Long-Range Regulatory Synergy Is Required to Allow Control of the TAC1 Locus by MEK/ERK Signalling in Sensory Neurones

Changes in the expression of the neuropeptide substance P (SP) in different populations of sensory neurones are associated with the progression of chronic inflammatory disease. Thus, understanding the genomic and cellular mechanisms driving the expression of the TAC1 gene, which encodes SP, in senso...

Full description

Bibliographic Details
Main Authors: Lynne Shanley, Scott Davidson, Marissa Lear, Anil Kumar Thotakura, Iain Joseph McEwan, Ruth A. Ross, Alasdair MacKenzie
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2010-12-01
Series:Neurosignals
Subjects:
Substance-P
TAC1 gene
Gene regulation
Regulatory synergy
Enhancer-promoter selectivity
MEK/ERK signalling
Comparative genomics
Sensory neurons
Capsaicin
Hyperalgesia
Online Access:http://www.karger.com/Article/FullText/322010

Internet

http://www.karger.com/Article/FullText/322010

Similar Items