Immune Checkpoints and Innovative Therapies in Glioblastoma

Immune Checkpoints and Innovative Therapies in Glioblastoma

Targeting the Immune Checkpoint molecules (ICs; CTLA-4, PD-1, PD-L1/2, and others) which provide inhibitory signals to T cells, dramatically improves survival in hard-to-treat tumors. The establishment of an immunosuppressive environment prevents endogenous immune response in glioblastoma; therefore...

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Bibliographic Details
Main Authors: Massimo Romani, Maria Pia Pistillo, Roberta Carosio, Anna Morabito, Barbara Banelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Oncology
Subjects:
glioblastoma
therapy
immune checkpoint
CTLA-4
PD-1
PD-L1
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00464/full

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https://www.frontiersin.org/article/10.3389/fonc.2018.00464/full

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