Rescuing Self: Transient Isolation and Autologous Transplantation of Bone Marrow Mitigates Radiation-Induced Hematopoietic Syndrome and Mortality in Mice

Rescuing Self: Transient Isolation and Autologous Transplantation of Bone Marrow Mitigates Radiation-Induced Hematopoietic Syndrome and Mortality in Mice

The inflamed bone marrow niche shortly after total body irradiation (TBI) is known to contribute to loss of hematopoietic stem cells in terms of their number and function. In this study, autologous bone marrow transfer (AL-BMT) was evaluated as a strategy for mitigating hematopoietic form of the acu...

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Bibliographic Details
Main Authors: Subhajit Ghosh, Namita Indracanti, Jayadev Joshi, Prem Kumar Indraganti
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
autologous bone marrow transfer
hematopoietic stem cells
homing
ionizing radiation
mitigation
hematopoietic syndrome
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01180/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01180/full

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