CD44 Expression Predicts Prognosis of Ovarian Cancer Patients Through Promoting Epithelial-Mesenchymal Transition (EMT) by Regulating Snail, ZEB1, and Caveolin-1

CD44 Expression Predicts Prognosis of Ovarian Cancer Patients Through Promoting Epithelial-Mesenchymal Transition (EMT) by Regulating Snail, ZEB1, and Caveolin-1

Objectives: CD44, a transmembrane glycoprotein, is involved in the generation of a stem cell niche and maintaining stem cell quiescence. The aim of this study was to evaluate its contribution to ovarian cancer prognosis and progression, as well as explore the possible mechanisms.Materials and Method...

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Bibliographic Details
Main Authors: Jiayi Zhou, Yan Du, Yiling Lu, Baoxin Luan, Congjian Xu, Yinhua Yu, Hongbo Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Oncology
Subjects:
CD44
expression
ovarian cancer
epithelial-to-mesenchymal transition
prognosis
survival
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00802/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00802/full

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