Enhancement of PSMA-Directed CAR Adoptive Immunotherapy by PD-1/PD-L1 Blockade

Enhancement of PSMA-Directed CAR Adoptive Immunotherapy by PD-1/PD-L1 Blockade

Chimeric antigen receptor (CAR) T cell therapy in hematologic malignancies has shown remarkable responses, but the same level of success has not been observed in solid tumors. A new prostate cancer model (Myc-CaP:PSMA(+)) and a second-generation anti-hPSMA human CAR T cells expressing a Click Beetle...

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Bibliographic Details
Main Authors: Inna Serganova, Ekaterina Moroz, Ivan Cohen, Maxim Moroz, Mayuresh Mane, Juan Zurita, Larissa Shenker, Vladimir Ponomarev, Ronald Blasberg
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Molecular Therapy: Oncolytics
Subjects:
prostate cancer
human PSMA
CAR T cells
anti-PD1
bioluminescence imaging
BLI
luciferase reporters
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770516300547

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http://www.sciencedirect.com/science/article/pii/S2372770516300547

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