Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases

Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases

Abstract Background In the urgent campaign to develop therapeutics against SARS-CoV-2, natural products have been an important source of new lead compounds. Results We herein identified two natural products, ginkgolic acid and anacardic acid, as inhibitors using a high-throughput screen targeting th...

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Bibliographic Details
Main Authors: Zinuo Chen, Qinghua Cui, Laura Cooper, Pin Zhang, Hyun Lee, Zhaoyu Chen, Yanyan Wang, Xiaoyun Liu, Lijun Rong, Ruikun Du
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Cell & Bioscience
Subjects:
SARS-CoV-2
Natural product
Ginkgolic acid
Anacardic acid
Papain‐like protease
Online Access:https://doi.org/10.1186/s13578-021-00564-x

Internet

https://doi.org/10.1186/s13578-021-00564-x

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