Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin

Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin

Eye drops of poorly soluble drugs are frequently formulated as suspensions. Bioavailability of suspended drug depends on the retention and dissolution of drug particles in the tear fluid, but these factors are still poorly understood. We investigated seven ocular indomethacin suspensions (experiment...

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Bibliographic Details
Main Authors: Elisa Toropainen, Sara J. Fraser-Miller, Dunja Novakovic, Eva M. Del Amo, Kati-Sisko Vellonen, Marika Ruponen, Tapani Viitala, Ossi Korhonen, Seppo Auriola, Laura Hellinen, Mika Reinisalo, Unni Tengvall, Stephanie Choi, Mohammad Absar, Clare Strachan, Arto Urtti
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceutics
Subjects:
ocular absorption
indomethacin
suspension
bioequivalence
dissolution
particle size
Online Access:https://www.mdpi.com/1999-4923/13/4/452

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https://www.mdpi.com/1999-4923/13/4/452

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