Hepatic Osteodystrophy—Molecular Mechanisms Proposed to Favor Its Development

Hepatic Osteodystrophy—Molecular Mechanisms Proposed to Favor Its Development

Almost all patients with chronic liver diseases (CLD) show altered bone metabolism. Depending on the etiology, this manifests in a severe osteoporosis in up to 75% of the affected patients. Due to high prevalence, the generic term hepatic osteodystrophy (HOD) evolved, describing altered bone metabol...

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Bibliographic Details
Main Authors: Sabrina Ehnert, Romina H. Aspera-Werz, Marc Ruoß, Steven Dooley, Jan G. Hengstler, Silvio Nadalin, Borna Relja, Andreas Badke, Andreas K. Nussler
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
bone metabolism
osteopenia
osteoporosis
liver disease
hepatic osteodystrophy
vitamin D metabolism
transforming growth factor beta (TGF-β)
bone morphogenetic proteins (BMPs)
histone deacetylases (HDACs)
sclerostin
Online Access:https://www.mdpi.com/1422-0067/20/10/2555

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https://www.mdpi.com/1422-0067/20/10/2555

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