Genome-wide analysis reveals selective modulation of microRNAs and mRNAs by histone deacetylase inhibitor in B cells induced to undergo class switch DNA recombination and plasma cell differentiation

Genome-wide analysis reveals selective modulation of microRNAs and mRNAs by histone deacetylase inhibitor in B cells induced to undergo class switch DNA recombination and plasma cell differentiation

As we have suggested, epigenetic factors, such as microRNAs (miRNAs), can interact with genetic programs to regulate B cell functions, thereby informing antibody and autoantibody responses. We have shown that histone deacetylase inhibitors (HDI) inhibit the differentiation events critical to the ma...

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Bibliographic Details
Main Authors: Tian eShen, Helia Nasrollahi Sanchez, Hong eZan, Paolo eCasali
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Immunology
Subjects:
B cell
epigenetics
microRNA
AID
histone acetylation
somatic hypermutation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00627/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00627/full

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