Adipose Stromal Cell-Secretome Counteracts Profibrotic Signals From IPF Lung Matrices

Adipose Stromal Cell-Secretome Counteracts Profibrotic Signals From IPF Lung Matrices

Introduction: Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease characterized by excess deposition and altered structure of extracellular matrix (ECM) in the lungs. The fibrotic ECM is paramount in directing resident cells toward a profibrotic phenotype. Collagens, an important part of...

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Bibliographic Details
Main Authors: Gwenda F. Vasse, Lisette Van Os, Marina De Jager, Marnix R. Jonker, Theo Borghuis, L. Tim Van Den Toorn, Pytrick Jellema, Eric S. White, Patrick Van Rijn, Martin C. Harmsen, Irene H. Heijink, Barbro N. Melgert, Janette K. Burgess
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
idiopathic pulmonary fibrosis (IPF)
adipose tissue-derived stromal/stem cells (ASCs)
decellularized lung matrices
denatured collagen
collagen hybridizing peptide
extracellular matrix (ECM)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.669037/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.669037/full

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