Fabrication and characterization of PLGA nanoparticles encapsulating large CRISPR–Cas9 plasmid

Fabrication and characterization of PLGA nanoparticles encapsulating large CRISPR–Cas9 plasmid

Abstract Background The clustered regularly interspaced short palindromic repeats (CRISPR) and Cas9 protein system is a revolutionary tool for gene therapy. Despite promising reports of the utility of CRISPR–Cas9 for in vivo gene editing, a principal problem in implementing this new process is deliv...

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Bibliographic Details
Main Authors: Ami Jo, Veronica M. Ringel-Scaia, Dylan K. McDaniel, Cassidy A. Thomas, Rui Zhang, Judy S. Riffle, Irving C. Allen, Richey M. Davis
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Nanobiotechnology
Subjects:
Nanoprecipitation
Transfection
CRISPR–Cas9
PLGA nanoparticles
Online Access:https://doi.org/10.1186/s12951-019-0564-1

Internet

https://doi.org/10.1186/s12951-019-0564-1

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