Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment

Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment

The precise relationship between epigenetic alterations and telomere dysfunction is still an extant question. Previously, we showed that eroded telomeres lead to differentiation instability in murine embryonic stem cells (mESCs) via DNA hypomethylation at pluripotency-factor promoters. Here, we unco...

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Bibliographic Details
Main Authors: Mélanie Criqui, Aditi Qamra, Tsz Wai Chu, Monika Sharma, Julissa Tsao, Danielle A Henry, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, Neil Winegarden, Mathieu Lupien, Lea Harrington
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
telomerase reverse transcriptase
telomeres
epigenetics
cell differentiation
mouse
embryonic stem cells
Online Access:https://elifesciences.org/articles/47333

Internet

https://elifesciences.org/articles/47333

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