Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC

Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC

The L-type calcium channel blocker fendiline has been shown to interfere with Ras-dependent signaling in K-Ras mutant cancer cells. Earlier studies from our lab had shown that treatment of pancreatic cancer cells with fendiline causes significant cytotoxicity and interferes with proliferation, survi...

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Bibliographic Details
Main Authors: Marwa Alhothali, Mevin Mathew, Geeta Iyer, Harshani R. Lawrence, Shengyu Yang, Srikumar Chellappan, Jaya Padmanabhan
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
pancreatic ductal adenocarcinoma (PDAC)
intracellular signaling
fendiline
visudyne
tivantinib
gemcitabine
cell cycle
anchorage independent growth
migration
self-renewal
Online Access:https://www.mdpi.com/1422-0067/20/10/2423

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https://www.mdpi.com/1422-0067/20/10/2423

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