Differential signaling of inducible nitric oxide synthase induction in Mycobacterium tuberculosis infected alveolar epithelial cell line A549 in response to cytokines IFN-γ, TNF-α and IL-1β

Differential signaling of inducible nitric oxide synthase induction in Mycobacterium tuberculosis infected alveolar epithelial cell line A549 in response to cytokines IFN-γ, TNF-α and IL-1β

Background: In earlier studies, it was shown that ex vivo Mycobacterium tuberculosis-infected type II alveolar epithelial cells generate de novo nitric oxide (NO), but the mycobactericidal quantity of NO was released only by stimulation of these cells with proinflammatory cytokines, i.e. IFN-γ, TNF-...

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Bibliographic Details
Main Authors: Sugata Roy, Sadhna Sharma, Monika Sharma, Mridula Bose
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2014-01-01
Series:International Journal of Mycobacteriology
Subjects:
Alveolar epithelial cell line A549
iNOS gene
STAT-1
NF-κB
Online Access:http://www.ijmyco.org/article.asp?issn=2212-5531;year=2014;volume=3;issue=1;spage=17;epage=24;aulast=Roy

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http://www.ijmyco.org/article.asp?issn=2212-5531;year=2014;volume=3;issue=1;spage=17;epage=24;aulast=Roy

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