Identification of Nucleophilic Probes for Protease-Mediated Transpeptidation

Identification of Nucleophilic Probes for Protease-Mediated Transpeptidation

Proteases have evolved to mediate the hydrolysis of peptide bonds but may perform transpeptidation in the presence of a proper nucleophilic molecule that can effectively compete with water to react with the acyl-enzyme intermediate. There have been several examples of protease-mediated transpeptidat...

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Bibliographic Details
Main Authors: Ga-eul Eom, Seokhee Kim
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Molecules
Subjects:
protease
transpeptidation
peptide ligation
nucleophilic probe
acyl-enzyme intermediate
DegP
Online Access:http://www.mdpi.com/1420-3049/23/9/2109

Internet

http://www.mdpi.com/1420-3049/23/9/2109

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