Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver

Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver

Polyploidy is a common feature in normal hepatocytes, however, the pathophysiological function of hepatic hyperpolyploidy is unclear. Here, the authors show that genotoxic stress induces accumulation of hyperpolyploid hepatocytes around the centrilobular region of the liver, which may indicate the o...

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Bibliographic Details
Main Authors: Heng Lin, Yen-Sung Huang, Jean-Michel Fustin, Masao Doi, Huatao Chen, Hui-Huang Lai, Shu-Hui Lin, Yen-Lurk Lee, Pei-Chih King, Hsien-San Hou, Hao-Wen Chen, Pei-Yun Young, Hsu-Wen Chao
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20572-8

Internet

https://doi.org/10.1038/s41467-020-20572-8

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