Diversity of Nonribosomal Peptide Synthetase Genes in the Microbial Metagenomes of Marine Sponges

Genomic mining revealed one major nonribosomal peptide synthetase (NRPS) phylogenetic cluster in 12 marine sponge species, one ascidian, an actinobacterial isolate and seawater. Phylogenetic analysis predicts its taxonomic affiliation to the actinomycetes and hydroxy-phenyl-glycine as a likely subst...

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Bibliographic Details
Main Authors: Ute Hentschel, Sheila Marie Pimentel-Elardo, Sebastian Proksch, Lubomir Grozdanov
Format: Article
Language:English
Published: MDPI AG 2012-05-01
Series:Marine Drugs
Subjects:
Online Access:http://www.mdpi.com/1660-3397/10/6/1192