Serp-1 Promotes Corneal Wound Healing by Facilitating Re-epithelialization and Inhibiting Fibrosis and Angiogenesis

Serp-1 Promotes Corneal Wound Healing by Facilitating Re-epithelialization and Inhibiting Fibrosis and Angiogenesis

Purpose: Chemical corneal injuries carry a high morbidity and commonly lead to visual impairment. Here, we investigate the role of Serp-1, a serine protease inhibitor, in corneal wound healing.Methods: An alkaline-induced corneal injury was induced in 14 mice. Following injury, five mice received da...

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Bibliographic Details
Main Authors: Brent Ju, Owen Guo, Dathe Z. Benissan-Messan, McKinley H. Shawver, Peng Chen, Bingchuan Geng, Siqi Wei, Jordan R. Yaron, Alexandra R. Lucas, Hua Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
corneal injury
neovascularization
Serp-1
PAI-1
corneal wound repair
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.649124/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.649124/full

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