microRNA-based autophagy inhibition as targeted therapy in pancreatic cancer

Pancreatic cancer is a malignancy with extremely low five-year survival rate. Pancreatic tumors maintain a high basal level of autophagy for survival and progression. Autophagy dysfunction leads to tumor progression in pancreatic cancer patients. Clinical trials with autophagy inhibitors, including...

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Bibliographic Details
Main Authors: Sanhong Liang, Xin Li, Chao Gao, Lexing Zhang
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220309926