Liensinine suppresses STAT3-dependent HK2 expression through elevating SHP-1 to induce apoptosis in hepatocellular carcinoma cells in vitro and in vivo

Liensinine suppresses STAT3-dependent HK2 expression through elevating SHP-1 to induce apoptosis in hepatocellular carcinoma cells in vitro and in vivo

Liensinine is an alkaloid from the embryos of Nelumbo nucifera Gaertn. Here, we revealed that liensinine induces hepatocellular carcinoma (HCC) cell apoptosis. Accumulation of ROS participates in liensinine-induced apoptosis. Mechanically, liensinine inhibits the expression of hexokinase 2 (HK2) and...

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Bibliographic Details
Main Authors: Guangwen Shu, Ji Hao, Wei Li, Lang Zhang, Yunhan Qiu, Xinzhou Yang
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Journal of Functional Foods
Subjects:
Apoptosis
Hepatocellular carcinoma
Liensinine
SHP-1
STAT3
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464618301531

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http://www.sciencedirect.com/science/article/pii/S1756464618301531

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