In Vivo Analysis of Optic Fissure Fusion in Zebrafish: Pioneer Cells, Basal Lamina, Hyaloid Vessels, and How Fissure Fusion is Affected by BMP

In Vivo Analysis of Optic Fissure Fusion in Zebrafish: Pioneer Cells, Basal Lamina, Hyaloid Vessels, and How Fissure Fusion is Affected by BMP

Colobomata, persistent optic fissures, frequently cause congenital blindness. Here, we focused on optic fissure fusion using in vivo time-lapse imaging in zebrafish. We identified the fusion initiating cells, which we termed “pioneer cells.” Based on morphology, localization, and downregulation of t...

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Bibliographic Details
Main Authors: Priska Eckert, Max D. Knickmeyer, Stephan Heermann
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
BMP
optic fissure
basal lamina
POM
pioneer cells
hyaloid vessel
Online Access:https://www.mdpi.com/1422-0067/21/8/2760

Internet

https://www.mdpi.com/1422-0067/21/8/2760

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