Pharmacological blockade of dopamine D1- or D2-receptor in the prefrontal cortex induces attentional impairment in the object-based attention test through different neuronal circuits in mice

Pharmacological blockade of dopamine D1- or D2-receptor in the prefrontal cortex induces attentional impairment in the object-based attention test through different neuronal circuits in mice

Abstract Dopamine is a key neurotransmitter that regulates attention through dopamine D1 and D2-receptors in the prefrontal cortex (PFC). We previously developed an object-based attention test (OBAT) to evaluate attention in mice. Disruption of the dopaminergic neuronal system in the PFC induced att...

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Bibliographic Details
Main Authors: Bolati Wulaer, Kazuo Kunisawa, Moeka Tanabe, Aika Yanagawa, Kuniaki Saito, Akihiro Mouri, Toshitaka Nabeshima
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Molecular Brain
Subjects:
Attention
OBAT
Prefrontal cortex
Dopamine
D1 receptor
D2 receptor
Online Access:https://doi.org/10.1186/s13041-021-00760-3

Internet

https://doi.org/10.1186/s13041-021-00760-3

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