Inhibition of post-transcriptional RNA processing by CDK inhibitors and its implication in anti-viral therapy.

Inhibition of post-transcriptional RNA processing by CDK inhibitors and its implication in anti-viral therapy.

Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and RNA polymerase II mediated transcription. Several pharmacological CDK inhibitors are currently in clinical trials as potential cancer therapeutics and some of them also exhibit antiviral effects. Olomoucine II and roscovitine,...

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Bibliographic Details
Main Authors: Jitka Holcakova, Petr Muller, Peter Tomasec, Roman Hrstka, Marta Nekulova, Vladimir Krystof, Miroslav Strnad, Gavin W G Wilkinson, Borivoj Vojtesek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3931720?pdf=render

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http://europepmc.org/articles/PMC3931720?pdf=render

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