Crystal structure of the yeast heterodimeric ADAT2/3 deaminase

Crystal structure of the yeast heterodimeric ADAT2/3 deaminase

Abstract Background The adenosine-to-inosine (A-to-I) editing in anticodons of tRNAs is critical for wobble base-pairing during translation. This modification is produced via deamination on A34 and catalyzed by the adenosine deaminase acting on tRNA (ADAT) enzyme. Eukaryotic ADATs are heterodimers c...

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Bibliographic Details
Main Authors: Xiwen Liu, Ruoyu Chen, Yujie Sun, Ran Chen, Jie Zhou, Qingnan Tian, Xuan Tao, Zhang Zhang, Guan-zheng Luo, Wei Xie
Format: Article
Language:English
Published: BMC 2020-12-01
Series:BMC Biology
Subjects:
Adenosine-to-inosine editing
tRNA modifications
ADAT
Deaminase
Molecular mechanism
Online Access:https://doi.org/10.1186/s12915-020-00920-2

Internet

https://doi.org/10.1186/s12915-020-00920-2

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