Transcriptional Regulation of Urokinase-type Plasminogen Activator Receptor by Hypoxia-Inducible Factor 1 Is Crucial for Invasion of Pancreatic and Liver Cancer

Transcriptional Regulation of Urokinase-type Plasminogen Activator Receptor by Hypoxia-Inducible Factor 1 Is Crucial for Invasion of Pancreatic and Liver Cancer

Angioinvasion is critical for metastasis with urokinase-type plasminogen activator receptor (uPAR) and tumor hypoxia-activated hypoxia-inducible factor 1 (HIF-1) as key players. Transcriptional control of uPAR expression by HIF has never been reported. The aim of the present study, therefore, was t...

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Bibliographic Details
Main Authors: Peter Büchler, Howard A. Reber, James S. Tomlinson, Oliver Hankinson, Georgis Kallifatidis, Helmut Friess, Ingrid Herr, Oscar J. Hines
Format: Article
Language:English
Published: Elsevier 2009-02-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558609800328

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http://www.sciencedirect.com/science/article/pii/S1476558609800328

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