Two-step grafting significantly enhances the survival of foetal dopaminergic transplants and induces graft-derived vascularisation in a 6-OHDA model of Parkinson's disease

Following transplantation of foetal primary dopamine (DA)-rich tissue for neurorestaurative treatment of Parkinson’s disease (PD), only 5–10% of the functionally relevant DAergic cells survive both in experimental models and in clinical studies. The current work tested how a two-step grafting protoc...

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Bibliographic Details
Main Authors: Fabian Büchele, Máté Döbrössy, Christina Hackl, Wei Jiang, Anna Papazoglou, Guido Nikkhah
Format: Article
Language:English
Published: Elsevier 2014-08-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000989