Linking Molecular Pathways and Large-Scale Computational Modeling to Assess Candidate Disease Mechanisms and Pharmacodynamics in Alzheimer's Disease

Linking Molecular Pathways and Large-Scale Computational Modeling to Assess Candidate Disease Mechanisms and Pharmacodynamics in Alzheimer's Disease

Introduction: While the prevalence of neurodegenerative diseases associated with dementia such as Alzheimer's disease (AD) increases, our knowledge on the underlying mechanisms, outcome predictors, or therapeutic targets is limited. In this work, we demonstrate how computational multi-scale bra...

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Bibliographic Details
Main Authors: Leon Stefanovski, Paul Triebkorn, Andreas Spiegler, Margarita-Arimatea Diaz-Cortes, Ana Solodkin, Viktor Jirsa, Anthony Randal McIntosh, Petra Ritter, for the Alzheimer's Disease Neuroimaging Initiative
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Computational Neuroscience
Subjects:
Alzheimer's disease
The Virtual Brain
PET
beta amyloid
EEG
MRI
Online Access:https://www.frontiersin.org/article/10.3389/fncom.2019.00054/full

Internet

https://www.frontiersin.org/article/10.3389/fncom.2019.00054/full

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