LncRNA NEAT1 Interacted With DNMT1 to Regulate Malignant Phenotype of Cancer Cell and Cytotoxic T Cell Infiltration via Epigenetic Inhibition of p53, cGAS, and STING in Lung Cancer

LncRNA NEAT1 Interacted With DNMT1 to Regulate Malignant Phenotype of Cancer Cell and Cytotoxic T Cell Infiltration via Epigenetic Inhibition of p53, cGAS, and STING in Lung Cancer

PurposeLung cancer is the main cause of cancer-related mortality worldwide. We report here the biological role of nuclear paraspeckle assembly transcript 1 (NEAT1) in the pathogenesis of lung cancer and the underlying mechanisms.MethodsReverse transcription–quantitative polymerase chain reaction (RT...

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Bibliographic Details
Main Authors: Fang Ma, Yi-Yu Lei, Meng-Ge Ding, Li-Hua Luo, Yang-Chun Xie, Xian-Ling Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Genetics
Subjects:
NEAT1
DNMT1
cGAS/STING pathway
lung cancer
mechanisms
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00250/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2020.00250/full

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