Recombinant IGF-1 Induces Sex-Specific Changes in Bone Composition and Remodeling in Adult Mice with <i>Pappa2</i> Deficiency

Recombinant IGF-1 Induces Sex-Specific Changes in Bone Composition and Remodeling in Adult Mice with <i>Pappa2</i> Deficiency

Deficiency of pregnancy-associated plasma protein-A2 (PAPP-A2), an IGF-1 availability regulator, causes postnatal growth failure and dysregulation of bone size and density. The present study aimed to determine the effects of recombinant murine IGF-1 (rmIGF-1) on bone composition and remodeling in co...

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Bibliographic Details
Main Authors: Leticia Rubio, Antonio Vargas, Patricia Rivera, Antonio J. López-Gambero, Rubén Tovar, Julian K. Christians, Stella Martín-de-las-Heras, Fernando Rodríguez de Fonseca, Julie A. Chowen, Jesús Argente, Juan Suárez
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
apatite
bone
collagen
growth
IGFBP
pappalysin
Online Access:https://www.mdpi.com/1422-0067/22/8/4048

Internet

https://www.mdpi.com/1422-0067/22/8/4048

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