Targeting hyaluronan for the treatment of pancreatic ductal adenocarcinoma

Progression of cancer is often associated with interactions between cancer cells and extracellular matrix (ECM) surrounding them. Increasing evidence has suggested that accumulation of hyaluronan (HA), a major component of ECM, provides a favorable microenvironment for cancer progression. Pancreatic...

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Bibliographic Details
Main Authors: Norihiro Sato, Xiao-Bo Cheng, Shiro Kohi, Atsuhiro Koga, Keiji Hirata
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383515300502