Antitumor effects of low‐dose tipifarnib on the mTOR signaling pathway and reactive oxygen species production in HIF‐1α‐expressing gastric cancer cells

Antitumor effects of low‐dose tipifarnib on the mTOR signaling pathway and reactive oxygen species production in HIF‐1α‐expressing gastric cancer cells

Farnesyltransferase inhibitors (FTIs) suppress tumor aggressiveness in several malignancies by inhibiting Ras signaling. However, treatment of cells with a low dose of the FTI tipifarnib suppresses the expression of hypoxia‐inducible factor‐1α (HIF‐1α) and results in antitumor effects without inhibi...

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Bibliographic Details
Main Authors: Noriyuki Egawa, Tomokazu Tanaka, Shohei Matsufuji, Kohei Yamada, Kotaro Ito, Hiroshi Kitagawa, Keiichiro Okuyama, Yoshihiko Kitajima, Hirokazu Noshiro
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:FEBS Open Bio
Subjects:
farnesyltransferase inhibitor
gastric cancer
HIF‐1α
mTOR
ROS
tipifarnib
Online Access:https://doi.org/10.1002/2211-5463.13154

Internet

https://doi.org/10.1002/2211-5463.13154

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