Potassium 2-(1-hydroxypentyl)-benzoate attenuates neuronal apoptosis in neuron–astrocyte co-culture system through neurotrophy and neuroinflammation pathway

Potassium 2-(1-hydroxypentyl)-benzoate attenuates neuronal apoptosis in neuron–astrocyte co-culture system through neurotrophy and neuroinflammation pathway

Potassium 2-(1-hydroxypentyl)-benzoate (d,l-PHPB), a new drug candidate for ischemic stroke at the phase II clinic trial, has been shown to protect neurons by inhibiting oxidative injury and reducing neuron apoptosis in previous studies. But the mechanisms of d,l-PHPB remain to be studied. In this s...

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Bibliographic Details
Main Authors: Dongmei Liu, Man Zhang, Xianfang Rong, Jiang Li, Xiaoliang Wang
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
d,l-PHPB
Oxygen-glucose deprivation
Neuron apoptosis
Astrocytes
Neuro > astrocyte co-culture
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383517302009

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http://www.sciencedirect.com/science/article/pii/S2211383517302009

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