Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.

Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.

Despite increasing evidence that autoreactive CD8 T-cells are involved in both the initiation of type 1 diabetes (T1D) and the destruction of beta-cells, direct evidence for their destructive role in-vivo is lacking. To address a destructive role for autoreactive CD8 T-cells in human disease, we ass...

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Bibliographic Details
Main Authors: Wendy W J Unger, Todd Pearson, Joana R F Abreu, Sandra Laban, Arno R van der Slik, Sacha Mulder-van der Kracht, Michel G D Kester, Dave V Serreze, Leonard D Shultz, Marieke Griffioen, Jan Wouter Drijfhout, Dale L Greiner, Bart O Roep
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3498321?pdf=render

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http://europepmc.org/articles/PMC3498321?pdf=render

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