Thrombomodulin: A Bifunctional Modulator of Inflammation and Coagulation in Sepsis

Deregulated interplay between inflammation and coagulation plays a pivotal role in the pathogenesis of sepsis. Therapeutic approaches that simultaneously target both inflammation and coagulation hold great promise for the treatment of sepsis. Thrombomodulin is an endogenous anticoagulant protein tha...

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Bibliographic Details
Main Authors: Takayuki Okamoto, Hironobu Tanigami, Koji Suzuki, Motomu Shimaoka
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Critical Care Research and Practice
Online Access:http://dx.doi.org/10.1155/2012/614545