P7C3 Inhibits LPS-Induced Microglial Activation to Protect Dopaminergic Neurons Against Inflammatory Factor-Induced Cell Death in vitro and in vivo

P7C3 Inhibits LPS-Induced Microglial Activation to Protect Dopaminergic Neurons Against Inflammatory Factor-Induced Cell Death in vitro and in vivo

Parkinson’s disease (PD) is the second most common neurodegenerative disorder. Although its pathogenesis remains unclear, growing evidencce suggests that microglia-mediated neuroinflammation contributes greatly to the progression of PD. P7C3, an aminopropyl carbazole, possesses significant neuroprot...

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Bibliographic Details
Main Authors: Chao Gu, Qingsong Hu, Jiayuan Wu, Chenchen Mu, Haigang Ren, Chun-Feng Liu, Guanghui Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
P7C3
lipopolysaccharide (LPS)
microglia
neuroinflammation
Parkinson’s disease (PD)
nuclear factor κB (NF-κB)
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00400/full

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https://www.frontiersin.org/article/10.3389/fncel.2018.00400/full

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