Entropic stabilization of proteins and its proteomic consequences.

Evolutionary traces of thermophilic adaptation are manifest, on the whole-genome level, in compositional biases toward certain types of amino acids. However, it is sometimes difficult to discern their causes without a clear understanding of underlying physical mechanisms of thermal stabilization of...

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Bibliographic Details
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2005-09-01
Series:PLoS Computational Biology
Online Access:http://dx.doi.org/10.1371/journal.pcbi.0010047