Fibrillar beta-amyloid peptide Aβ<sub>1–40 </sub>activates microglial proliferation via stimulating TNF-α release and H<sub>2</sub>O<sub>2 </sub>derived from NADPH oxidase: a cell culture study

Fibrillar beta-amyloid peptide Aβ<sub>1–40 </sub>activates microglial proliferation via stimulating TNF-α release and H<sub>2</sub>O<sub>2 </sub>derived from NADPH oxidase: a cell culture study

<p>Abstract</p> <p>Background</p> <p>Alzheimer's disease is characterized by the accumulation of neuritic plaques, containing activated microglia and β-amyloid peptides (Aβ). Fibrillar Aβ can activate microglia, resulting in production of toxic and inflammatory med...

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Bibliographic Details
Main Authors:	Sharpe Martyn, Tickler Anna, Mander Palwinder K, Jekabsone Aiste, Brown Guy C
Format:	Article
Language:	English
Published:	BMC 2006-09-01
Series:	Journal of Neuroinflammation
Online Access:	http://www.jneuroinflammation.com/content/3/1/24

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