SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells

SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells

Summary: Oncoproteins such as the BRAFV600E kinase endow cancer cells with malignant properties, but they also create unique vulnerabilities. Targeting of BRAFV600E-driven cytoplasmic signaling networks has proved ineffective, as patients regularly relapse with reactivation of the targeted pathways....

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Bibliographic Details
Main Authors: Kathleen Klotz-Noack, Bertram Klinger, Maria Rivera, Natalie Bublitz, Florian Uhlitz, Pamela Riemer, Mareen Lüthen, Thomas Sell, Katharina Kasack, Bastian Gastl, Sylvia S.S. Ispasanie, Tincy Simon, Nicole Janssen, Matthias Schwab, Johannes Zuber, David Horst, Nils Blüthgen, Reinhold Schäfer, Markus Morkel, Christine Sers
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Cell Reports
Subjects:
MAPK signaling
Chk1
replication stress
R loops
cell death
synthetic lethality
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720311736

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http://www.sciencedirect.com/science/article/pii/S2211124720311736

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