miREM: an expectation-maximization approach for prioritizing miRNAs associated with gene-set

miREM: an expectation-maximization approach for prioritizing miRNAs associated with gene-set

Abstract Background The knowledge of miRNAs regulating the expression of sets of mRNAs has led to novel insights into numerous and diverse cellular mechanisms. While a single miRNA may regulate many genes, one gene can be regulated by multiple miRNAs, presenting a complex relationship to model for a...

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Bibliographic Details
Main Authors: Luqman Hakim Abdul Hadi, Quy Xiao Xuan Lin, Tri Tran Minh, Marie Loh, Hong Kiat Ng, Agus Salim, Richie Soong, Touati Benoukraf
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Bioinformatics
Subjects:
Gene regulation
miRNA
Expectation-maximization
Online Access:http://link.springer.com/article/10.1186/s12859-018-2292-1

Internet

http://link.springer.com/article/10.1186/s12859-018-2292-1

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