Mechanisms of Hyperhomocysteinemia Induced Skeletal Muscle Myopathy after Ischemia in the CBS−/+ Mouse Model

Mechanisms of Hyperhomocysteinemia Induced Skeletal Muscle Myopathy after Ischemia in the CBS−/+ Mouse Model

Although hyperhomocysteinemia (HHcy) elicits lower than normal body weights and skeletal muscle weakness, the mechanisms remain unclear. Despite the fact that HHcy-mediated enhancement in ROS and consequent damage to regulators of different cellular processes is relatively well established in other...

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Bibliographic Details
Main Authors: Sudhakar Veeranki, Suresh C. Tyagi
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:International Journal of Molecular Sciences
Subjects:
homocysteine
skeletal muscle
PGC-1α
PPARγ
nitrotyrosylation
ischemia
CBS
CSE
MTHFR
H2S
Online Access:http://www.mdpi.com/1422-0067/16/1/1252

Internet

http://www.mdpi.com/1422-0067/16/1/1252

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