Contrasting roles of H3K4me3 and H3K9me3 in regulation of apoptosis and gemcitabine resistance in human pancreatic cancer cells

Contrasting roles of H3K4me3 and H3K9me3 in regulation of apoptosis and gemcitabine resistance in human pancreatic cancer cells

Abstract Background Pancreas ductal adenocarcinoma (PDAC) has the most dismal prognosis among all human cancers since it is highly resistant to chemotherapy, radiotherapy and immunotherapy. The anticipated consequence of all therapies is induction of tumor apoptosis. The highly resistance nature of...

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Bibliographic Details
Main Authors: Chunwan Lu, Dafeng Yang, Maria E. Sabbatini, Aaron H. Colby, Mark W. Grinstaff, Nicholas H. Oberlies, Cedric Pearce, Kebin Liu
Format: Article
Language:English
Published: BMC 2018-02-01
Series:BMC Cancer
Subjects:
H3K9me3
H3K4me3
Gemcitabine
Chemoresistance
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s12885-018-4061-y

Internet

http://link.springer.com/article/10.1186/s12885-018-4061-y

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