Molecular Basis of AmpC β-Lactamase Induction by Avibactam in <i>Pseudomonas aeruginosa</i>: PBP Occupancy, Live Cell Binding Dynamics and Impact on Resistant Clinical Isolates Harboring PDC-X Variants
Avibactam belongs to the new class of diazabicyclooctane β-lactamase inhibitors. Its inhibitory spectrum includes class A, C and D enzymes, including <i>P. aeruginosa</i> AmpC. Nonetheless, recent reports have revealed strain-dependent avibactam AmpC induction. In the present work, we wa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-03-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/6/3051 |