Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes

Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes

Abstract Human noroviruses are non-enveloped, single-strand RNA viruses that cause pandemic outbreaks of acute gastroenteritis. A bivalent vaccine containing GI.1 and GII.4 virus-like particles (VLPs) has been shown to be safe and highly immunogenic, but its efficacy and durability have been limited...

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Bibliographic Details
Main Authors: Raffaello Verardi, Lisa C. Lindesmith, Yaroslav Tsybovsky, Jason Gorman, Gwo-Yu Chuang, Caitlin E. Edwards, Paul D. Brewer-Jensen, Michael L. Mallory, Li Ou, Arne Schön, Wei Shi, Ena S. Tully, George Georgiou, Ralph S. Baric, Peter D. Kwong
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-020-00260-w

Internet

https://doi.org/10.1038/s41541-020-00260-w

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