Of Lymph Nodes and CLL Cells: Deciphering the Role of CCR7 in the Pathogenesis of CLL and Understanding Its Potential as Therapeutic Target

Of Lymph Nodes and CLL Cells: Deciphering the Role of CCR7 in the Pathogenesis of CLL and Understanding Its Potential as Therapeutic Target

The lymph node (LN) is an essential tissue for achieving effective immune responses but it is also critical in the pathogenesis of chronic lymphocytic leukemia (CLL). Within the multitude of signaling pathways aberrantly regulated in CLL the homeostatic axis composed by the chemokine receptor CCR7 a...

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Bibliographic Details
Main Authors: Carlos Cuesta-Mateos, Jennifer R. Brown, Fernando Terrón, Cecilia Muñoz-Calleja
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
CCR7
CLL (chronic lymphocytic leukemia)
lymph node
pathophysiology
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.662866/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.662866/full

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