FAT4 silencing promotes epithelial-to-mesenchymal transition and invasion via regulation of YAP and β-catenin activity in ovarian cancer

FAT4 silencing promotes epithelial-to-mesenchymal transition and invasion via regulation of YAP and β-catenin activity in ovarian cancer

Abstract Background The adhesion molecule, FAT4, has a tumor suppressor function with a critical role in the epithelial-to-mesenchymal-transition (EMT) and anti-malignant growth in several cancers. No study has investigated yet its role in epithelial ovarian cancer (EOC) progression. In the present...

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Bibliographic Details
Main Authors: Shika Hanif Malgundkar, Ikram Burney, Mansour Al Moundhri, Moza Al Kalbani, Ritu Lakhtakia, Aikou Okamoto, Yahya Tamimi
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Cancer
Subjects:
FAT4
Silencing
Invasion
YAP
Ovarian cancer
Online Access:http://link.springer.com/article/10.1186/s12885-020-06900-7

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http://link.springer.com/article/10.1186/s12885-020-06900-7

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