Genetic Targeting of Arginase-II in Mouse Prevents Renal Oxidative Stress and Inflammation in Diet-Induced Obesity

Genetic Targeting of Arginase-II in Mouse Prevents Renal Oxidative Stress and Inflammation in Diet-Induced Obesity

Obesity is associated with development and progression of chronic kidney disease (CKD). Recent evidence demonstrates that enhanced levels of the L-arginine:ureahydrolase, including the two isoenzymes arginase-I (Arg-I) and arginase-II (Arg-II) in vascular endothelial cells promote uncoupling of endo...

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Bibliographic Details
Main Authors: Ji Huang, Angana Rajapakse, Yuyan Xiong, Jean-Pierre Montani, Francois Verrey, Xiu-Fen Ming, Zhihong Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Physiology
Subjects:
Arginase
Obesity
Oxidative Stress
Adhesion molecules
Renal disease
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00560/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00560/full

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