STAT4 targets KISS1 to promote the apoptosis of ovarian granulosa cells

STAT4 targets KISS1 to promote the apoptosis of ovarian granulosa cells

Abstract Background In mammals, it is known that the estradiol-17β (E2) is mainly synthetized in ovarian granulosa cells (GCs), and the excessive apoptosis of GCs induces the follicular atresia. Many studies have implicated the essential role of KISS1, with the pro-synthetic effect of E2 and the ant...

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Bibliographic Details
Main Authors: Yao Jiang, Xiaoping Xin, Xiangchun Pan, Ailing Zhang, Zhe Zhang, Jiaqi Li, Xiaolong Yuan
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Journal of Ovarian Research
Subjects:
STAT4
KISS1
Cell apoptosis
Synthesis of E2
Ovarian granulosa cells
Online Access:http://link.springer.com/article/10.1186/s13048-020-00741-5

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http://link.springer.com/article/10.1186/s13048-020-00741-5

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