Elucidating the Importance of DOT1L Recruitment in MLL-AF9 Leukemia and Hematopoiesis

Elucidating the Importance of DOT1L Recruitment in MLL-AF9 Leukemia and Hematopoiesis

<i>MLL1 (KMT2a)</i> gene rearrangements underlie the pathogenesis of aggressive MLL-driven acute leukemia. AF9, one of the most common MLL-fusion partners, recruits the histone H3K79 methyltransferase DOT1L to MLL target genes, constitutively activating transcription of pro-leukemic targ...

Full description

Bibliographic Details
Main Authors: Sierrah M. Grigsby, Ann Friedman, Jennifer Chase, Bridget Waas, James Ropa, Justin Serio, Chenxi Shen, Andrew G. Muntean, Ivan Maillard, Zaneta Nikolovska-Coleska
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
Dot1l
MLL-rearrangement leukemia
protein-protein interaction
hematopoiesis
Online Access:https://www.mdpi.com/2072-6694/13/4/642

Internet

https://www.mdpi.com/2072-6694/13/4/642

Similar Items