Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease.

Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease.

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The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds that risk-factors for severe COVID-19 disease courses, i.e. male sex, older age and sedentary life style are associated with higher prostaglandin E2 (PGE2) serum levels in blood samples from un...

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Bibliographic Details
Main Authors: Melanie Ricke-Hoch, Elisabeth Stelling, Lisa Lasswitz, Antonia P Gunesch, Martina Kasten, Francisco J Zapatero-Belinchón, Graham Brogden, Gisa Gerold, Thomas Pietschmann, Virginie Montiel, Jean-Luc Balligand, Federica Facciotti, Emilio Hirsch, Thomas Gausepohl, Husni Elbahesh, Guus F Rimmelzwaan, Anne Höfer, Mark P Kühnel, Danny Jonigk, Julian Eigendorf, Uwe Tegtbur, Lena Mink, Michaela Scherr, Thomas Illig, Axel Schambach, Tobias J Pfeffer, Andres Hilfiker, Axel Haverich, Denise Hilfiker-Kleiner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0255335

Internet

https://doi.org/10.1371/journal.pone.0255335

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