Identification of transmissible proteotoxic oligomer-like fibrils that expand conformational diversity of amyloid assemblies
Nguyen et al identified cytotoxic amyloid fibrils with oligomer-like characteristics, which were assembled from an islet amyloid polypeptide (IAPP) derivative containing an Asn-to-Gln substitution (N21Q). They presented evidence to show that these stable fibrils expand the conformational diversity o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-08-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02466-7 |